HDAC1-IN-5

CAT: 0931-MF-0048822-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0048822-01Size:25 mg
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PRICE
AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Target
Others|||Microtubule Associated|||Apoptosis|||Caspase|||HDAC
Related Pathways
Apoptosis|||DNA Damage/DNA Repair|||Chromatin/Epigenetic|||Cytoskeletal Signaling|||Others|||Proteases/Proteasome
Bioactivity
HDAC1-IN-5, a potent inhibitor of HDAC1 with an IC50 value of 15 nM, also exhibits inhibitory activity towards HDAC6 with an IC50 value of 20 nM. In cancer cells, HDAC1-IN-5 enhances the acetylation of both histone H3 and ?-tubulin, leading to the activation of caspase 3 and induction of apoptosis. Additionally, HDAC1-IN-5 binds with DNA, causing chromatin damage. Furthermore, it demonstrated strong inhibitory activity against tumor growth in xenograft mice. [1]
Molecular Formula
C20H21N3O2S
Molecular Weight
367.46
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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