G721-0282

• Target:

  Glycosidase|||CDK|||Survivin|||Bcl-2 Family|||NF-?B|||p38 MAPK|||Apoptosis|||STAT|||COX|||ERK

• Related Pathways:

  JAK/STAT signaling|||Immunology/Inflammation|||Metabolism|||MAPK|||NF-?B|||Cell Cycle/Checkpoint|||Neuroscience|||Stem Cells|||Apoptosis

• Bioactivity:

  G721-0282 is an orally active inhibitor of CHI3L1 that reduces the expression of inflammatory proteins and cytokines. It suppresses the activation of the NF-?B signaling pathway, inhibits neuroinflammation, and decreases anxiety-related behaviors. Additionally, G721-0282 significantly curtails the proliferation of osteosarcoma (OS) cells by inhibiting the STAT3 signaling pathway and induces apoptosis in OS cells by upregulating pro-apoptotic protein levels while downregulating anti-apoptotic protein levels. This compound is useful in the study of neuroinflammatory diseases and cancer.

• Smiles:

  O=C1C2=C (SCC (=O) NCC=C) C (=CN=C2N (C (=O) N1C) C) CCCC

• Molecular Formula:

  C18H24N4O3S

• Molecular Weight:

  376.47

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  946378-12-7