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G721-0282

CAT: 0931-T211225-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T211225-01Size:10 mg
Selected
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
946378-12-7
Target
Glycosidase, CDK, Survivin, Bcl-2 Family, NF-κB, p38 MAPK, Apoptosis, STAT, COX, ERK
Related Pathways
JAK/STAT signaling, Immunology/Inflammation, Metabolism, MAPK, NF-κB, Cell Cycle/Checkpoint, Neuroscience, Stem Cells, Apoptosis
Bioactivity
G721-0282 is an orally active inhibitor of CHI3L1 that reduces the expression of inflammatory proteins and cytokines. It suppresses the activation of the NF-κB signaling pathway, inhibits neuroinflammation, and decreases anxiety-related behaviors. Additionally, G721-0282 significantly curtails the proliferation of osteosarcoma (OS) cells by inhibiting the STAT3 signaling pathway and induces apoptosis in OS cells by upregulating pro-apoptotic protein levels while downregulating anti-apoptotic protein levels. This compound is useful in the study of neuroinflammatory diseases and cancer.
Smiles
O=C1C2=C(SCC(=O)NCC=C)C(=CN=C2N(C(=O)N1C)C)CCCC
Molecular Formula
C18H24N4O3S
Molecular Weight
376.47
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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