CDK2-IN-12
CAT:
804-HY-150573
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
CDK2-IN-12
- CAS Number: 2410402-88-7
- UNSPSC Description: CDK2-IN-12 (compound 10b) is a potent CDK2 inhibitor, with an IC50 of 11.6 μM. CDK2-IN-12 inhibits hCA (carbonic anhydrase) isoforms I, II, IX and XII, with KI values of 3534, 638.4, 44.3, and 48.8 nM. CDK2-IN-12 shows anticancer activity[1].
- Target Antigen: Carbonic Anhydrase; CDK
- Type: Reference compound
- Related Pathways: Cell Cycle/DNA Damage;Metabolic Enzyme/Protease
- Applications: Cancer-Kinase/protease
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/cdk2-in-12.html
- Solubility: 10 mM in DMSO
- Smiles: O=S(C1=CC=C(/N=N/C2=C3N=C(C4=CC=C(C)C=C4)C(C#N)=C(N)N3N=C2N)C=C1)(N)=O
- Molecular Weight: 447.47
- References & Citations: [1]Said MA, et al. Sulfonamide-based ring-fused analogues for CAN508 as novel carbonic anhydrase inhibitors endowed with antitumor activity: Design, synthesis, and in vitro biological evaluation. Eur J Med Chem. 2020 Mar 1;189:112019.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported