Cys-C-cGMP

CAT: 0804-HY-150411Size: 1 EachDry Ice: NoHazardous: No

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Description

Cys-C-cGMP is a autophagy tag for AUTACs. Cys-C-cGMP can increase the K63-linked ubiquitination of mitochondria in HeLa cells[1].

CAS Number

2241669-85-0

UNSPSC

12352005

Target

AUTACs

Type

Reference compound

Related Pathways

Autophagy; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cys-c-cgmp.html

Solubility

10 mM in DMSO

Smiles

NC(N1)=NC2=C(N=C(SC[C@H](NC(C)=O)C(O)=O)N2[C@H]3[C@H](O)[C@H](OP4(O)=O)[C@@H](CO4)O3)C1=O

Molecular Formula

C15H19N6O10PS

Molecular Weight

506.38

References & Citations

[1]Takahashi D, et al. AUTACs: Cargo-Specific Degraders Using Selective Autophagy. Mol Cell. 2019 Dec 5;76 (5) :797-810.e10.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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