MANT-cGMP

• Description :

  MANT-cGMP, a ribose-substituted nucleotide, is an adenylyl cyclase (AC) inhibitor with a Ki of 100 μM and a pKi of 4. MANT-cGMP can be used for the study of heart failure, cancer, and neurological disorders[1].

• UNSPSC :

  12352005

• Target :

  Adenylate Cyclase

• Related Pathways :

  GPCR/G Protein

• Field of Research :

  Cancer; Neurological Disease; Cardiovascular Disease

• Smiles :

  O=C(C(C=CC=C1)=C1NC)O[C@H]2[C@@](N3C(NC(N)=NC4=O)=C4N=C3)([H])O[C@@](CO5)([H])[C@@]2([H])O[P]5(O)=O

• Molecular Formula :

  C18H19N6O8P

• Molecular Weight :

  478.35

• References & Citations :

  [1]Wang JL, et al. A conformational transition in the adenylyl cyclase catalytic site yields different binding modes for ribosyl-modified and unmodified nucleotide inhibitors. Bioorg Med Chem. 2007 Apr 15;15 (8) :2993-3002.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [83707-15-7]