MANT-cGMP

• Description:

  MANT-cGMP, a ribose-substituted nucleotide, is an adenylyl cyclase (AC) inhibitor with a Ki of 100 μM and a pKi of 4. MANT-cGMP can be used for the study of heart failure, cancer, and neurological disorders[1].

• UNSPSC:

  12352005

• Target:

  Adenylate Cyclase

• Related Pathways:

  GPCR/G Protein

• Field of Research:

  Cancer; Neurological Disease; Cardiovascular Disease

• Smiles:

  O=C (C (C=CC=C1) =C1NC) O[C@H]2[C@@] (N3C (NC (N) =NC4=O) =C4N=C3) ([H]) O[C@@] (CO5) ([H]) [C@@]2 ([H]) O[P]5 (O) =O

• Molecular Formula:

  C18H19N6O8P

• Molecular Weight:

  478.35

• References & Citations:

  [1]Wang JL, et al. A conformational transition in the adenylyl cyclase catalytic site yields different binding modes for ribosyl-modified and unmodified nucleotide inhibitors. Bioorg Med Chem. 2007 Apr 15;15 (8) :2993-3002.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  83707-15-7