Cys-McMMAF

Cys-McMMAF

• CAS Number: 1160590-05-5
• UNSPSC Description: Cys-McMMAF is the released payload of AlMcMMAF, an anti-5T4 humanized A1 antibody conjugated to the microtubule disrupting MMAF (HY-15579) via a maleimidocaproyl linker. Cys-McMMAF has antitumor efficacy in two tumor mouse models (H1975 and MDA-MB-361-DYT2 models)[1].
• Target Antigen: Microtubule/Tubulin
• Type: ADC Related
• Related Pathways: Cell Cycle/DNA Damage;Cytoskeleton
• Applications: Cancer-programmed cell death
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/cys-mcmmaf.html
• Solubility: DMSO : 200 mg/mL (ultrasonic)
• Smiles: OC([C@H](CC1=CC=CC=C1)NC([C@H](C)[C@H]([C@@]2([H])N(CCC2)C(C[C@@H](OC)[C@H]([C@@H](C)CC)N(C)C([C@H](C(C)C)NC([C@H](C(C)C)N(C)C(CCCCCN3C(C(CC3=O)SC[C@H](N)C(O)=O)=O)=O)=O)=O)=O)OC)=O)=O
• Molecular Weight: 1046.32
• References & Citations: [1]Leal M, et al. Preclinical Development of an anti-5T4 Antibody-Drug Conjugate: Pharmacokinetics in Mice, Rats, and NHP and Tumor/Tissue Distribution in Mice. Bioconjug Chem. 2015 Nov 18;26(11):2223-32.
• Shipping Conditions: Blue Ice
• Clinical Information: No Development Reported