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Sildenafil (citrate) -d8

CAT: 0804-HY-15025ASSize: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-15025ASSize:1 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Sildenafil (citrate) -d8 is the deuterium labeled Sildenafil citrate[1]. Sildenafil citrate is a potent phosphodiesterase type 5 (PDE5) inhibitor with IC50 of 5.22 nM.
CAS Number
1215071-03-6
Product Name Alternative
UK-92480 (citrate) -d8
UNSPSC
12352005
Target
Apoptosis; Autophagy; Bacterial; Phosphodiesterase (PDE)
Type
Isotope-Labeled Compounds
Related Pathways
Anti-infection; Apoptosis; Autophagy; Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Cardiovascular Disease
Solubility
10 mM in DMSO
Smiles
OC(CC(C(O)=O)(O)CC(O)=O)=O.CCOC1=C(C(NC2=C3N(N=C2CCC)C)=NC3=O)C=C(C=C1)S(=O)(N4C([2H])([2H])C([2H])([2H])N(C([2H])([2H])C4([2H])[2H])C)=O
Molecular Formula
C28H30D8N6O11S
Molecular Weight
674.75
References & Citations
[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-216.|[2]Wang Z, et al. The Selectivity and Potency of the New PDE5 Inhibitor TPN729MA. J Sex Med. 2013 Nov;10 (11) :2790-7.|[3]Li BB, et al. Sildenafil potentiates the proliferative effect of porcine pulmonary artery smooth muscle cells induced by serotonin in vitro. Chin Med J (Engl) . 2011 Sep124 (17) :2733-40.|[4]Moretti R, et al. Sildenafil, a cyclic GMP phosphodiesterase inhibitor, induces microglial modulation after focal ischemia in the neonatal mouse brain. J Neuroinflammation. 2016 Apr 2813 (1) :95.|[5]Korkmaz MF, et al. The Effect of Sildenafil on Recuperation from Sciatic Nerve Injury in Rats. Balkan Med J. 2016 Mar33 (2) :204-11.
Shipping Conditions
Room temperature
Scientific Category
Isotope-Labeled Compounds
Clinical Information
No Development Reported

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