N-Desmethyl Sildenafil-d8

N-Desmethyl Sildenafil-d8

• CAS Number: 1185168-06-2
• UNSPSC Description: N-Desmethyl Sildenafil-d8 is the deuterium labeled N-Desmethyl Sildenafil (HY-117605). N-Desmethyl Sildenafil is a major metabolite of Sildenafil. Sildenafil is a potent phosphodiesterase type 5 (PDE5) inhibitor[1][2][3].
• Target Antigen: Isotope-Labeled Compounds; Phosphodiesterase (PDE)
• Type: Isotope-Labeled Compounds
• Related Pathways: Metabolic Enzyme/Protease;Others
• Field of Research: Cancer; Neurological Disease
• Solubility: 10 mM in DMSO
• Smiles: CCCC1=NN(C)C2=C1NC(C3=C(C=CC(S(=O)(N4C([2H])([2H])C([2H])([2H])NC([2H])([2H])C4([2H])[2H])=O)=C3)OCC)=NC2=O
• Molecular Weight: 468.60
• References & Citations: [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216.|[2]Péter Barabás, et al. Sildenafil, N-desmethyl-sildenafil and Zaprinast enhance photoreceptor response in the isolated rat retina. Neurochem Int. 2003 Nov;43(6):591-5. |[3]Rikako Takahiro, et al. Contribution of CYP3A isoforms to dealkylation of PDE5 inhibitors: a comparison between sildenafil N-demethylation and tadalafil demethylenation. Biol Pharm Bull. 2015;38(1):58-65.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported