Sildenafil-d5

• Description:

  Sildenafil-d5 (UK-92480-d5) is deuterium labeled Sildenafil. Sildenafil (UK-92480) is a potent phosphodiesterase type 5 (PDE5) inhibitor with an IC50 of 5.22 nM.

• Product Name Alternative:

  UK-92480-d5

• UNSPSC:

  12352005

• Target:

  Apoptosis; Autophagy; Bacterial; Isotope-Labeled Compounds; Phosphodiesterase (PDE)

• Related Pathways:

  Anti-infection; Apoptosis; Autophagy; Metabolic Enzyme/Protease; Others

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cardiovascular Disease; Cancer

• Smiles:

  O=C1N=C (C2=C (OC ([2H]) ([2H]) C ([2H]) ([2H]) [2H]) C=CC (S (=O) (N3CCN (CC3) C) =O) =C2) NC4=C1N (C) N=C4CCC

• Molecular Formula:

  C22H25D5N6O4S

• Molecular Weight:

  479.61

• References & Citations:

  [1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53 (2) :211-216.|[2]Moretti R, et al. Sildenafil, a cyclic GMP phosphodiesterase inhibitor, induces microglial modulation after focal ischemia in the neonatal mouse brain. J Neuroinflammation. 2016 Apr 28;13 (1) :95.|[3]Korkmaz MF, et al. The Effect of Sildenafil on Recuperation from Sciatic Nerve Injury in Rats. Balkan Med J. 2016 Mar;33 (2) :204-11.|[4]Wang Z, et al. The Selectivity and Potency of the New PDE5 Inhibitor TPN729MA. J Sex Med. 2013 Nov;10 (11) :2790-7.|[5]Li BB, et al. Sildenafil potentiates the proliferative effect of porcine pulmonary artery smooth muscle cells induced by serotonin in vitro. Chin Med J (Engl) . 2011 Sep;124 (17) :2733-40.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Isotope-Labeled Compounds

• Clinical Information:

  No Development Reported

• CAS Number:

  951385-70-9