Sildenafil (Standard)

CAT: 0804-HY-15025R-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0804-HY-15025R-01Size:10 mg
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Description
Sildenafil (Standard) is the analytical standard of Sildenafil. This product is intended for research and analytical applications. Sildenafil (UK-92480) is a potent phosphodiesterase type 5 (PDE5) inhibitor with an IC50 of 5.22 nM.
CAS Number
[139755-83-2]
UNSPSC
12352100
Target
Apoptosis; Autophagy; Bacterial; Phosphodiesterase (PDE) ; Reference Standards
Related Pathways
Anti-infection; Apoptosis; Autophagy; Metabolic Enzyme/Protease; Others
Field of Research
Cardiovascular Disease; Cancer
Smiles
O=C1C(N(C)N=C2CCC)=C2N=C(C3=CC(S(=O)(N4CCN(C)CC4)=O)=CC=C3OCC)N1
Molecular Formula
C22H30N6O4S
Molecular Weight
474.58
References & Citations
[1]Wang Z, et al. The Selectivity and Potency of the New PDE5 Inhibitor TPN729MA. J Sex Med. 2013 Nov;10 (11) :2790-7.|[2]Li BB, et al. Sildenafil potentiates the proliferative effect of porcine pulmonary artery smooth muscle cells induced by serotonin in vitro. Chin Med J (Engl) . 2011 Sep;124 (17) :2733-40.|[3]Moretti R, et al. Sildenafil, a cyclic GMP phosphodiesterase inhibitor, induces microglial modulation after focal ischemia in the neonatal mouse brain. J Neuroinflammation. 2016 Apr 28;13 (1) :95.|[4]Korkmaz MF, et al. The Effect of Sildenafil on Recuperation from Sciatic Nerve Injury in Rats. Balkan Med J. 2016 Mar;33 (2) :204-11.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards

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