RyR2 stabilizer-1

• UNSPSC Description:

  RyR2 stabilizer-1 (compound 12a) is a potent RyR2 stabilizer and SERCA2a activator with EC50s of 2.7 μM for RyR2 and 383 nM for SERCA2. RyR2 stabilizer-1 inhibits Ca2+ leakage from the SR RyR2 while promoting SERCA2 to pump Ca2+ back to SR, which make RyR2 stabilizer-1 possible to prevent cardiac arrhythmias[1].

• Target Antigen:

  Calcium Channel

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel;Neuronal Signaling

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Cardiovascular Disease

• Assay Protocol:

  https://www.medchemexpress.com/ryr2-stabilizer-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  OC1(CCCCN(CCCCN2CC3=C(SCC2)C=CC(OC)=C3)CCCCC4(CC4)O)CC1

• Molecular Weight:

  490.74

• References & Citations:

  [1]Gyuzel Y. Mitronova, et al. 1,4-Benzothiazepines with Cyclopropanol Groups and Their Structural Analogues Exhibit Both RyR2-Stabilizing and SERCA2aStimulating Activities. Journal of Medicinal Chemistry. 2023， Article ASAP.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  3012675-16-7