RyR2 stabilizer-1

• Target:

  Calcium Channel

• Related Pathways:

  Membrane transporter/Ion channel|||Metabolism

• Bioactivity:

  RyR2 stabilizer-1 (Compound12a) is a potent stabilizer of RyR2 and an activator of SERCA2a, with EC50 values of 2.7 ?M for RyR2 and 383 nM for SERCA2. This compound inhibits the leakage of Ca2+ through SR RyR2 while promoting the reuptake of Ca2+ into the SR by SERCA2, suggesting its potential in preventing arrhythmias.

• Smiles:

  OC1(CCCCN(CCCCN2CC3=CC(OC)=CC=C3SCC2)CCCCC4(O)CC4)CC1

• Molecular Formula:

  C28H46N2O3S

• Molecular Weight:

  490.74

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  3012675-16-7