RyR2 stabilizer-1

CAT: 0931-MF-0115952-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0115952-01Size:10 mg
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CAS Number
3012675-16-7
Target
Calcium Channel
Related Pathways
Membrane transporter/Ion channel|||Metabolism
Bioactivity
RyR2 stabilizer-1 (Compound12a) is a potent stabilizer of RyR2 and an activator of SERCA2a, with EC50 values of 2.7 ?M for RyR2 and 383 nM for SERCA2. This compound inhibits the leakage of Ca2+ through SR RyR2 while promoting the reuptake of Ca2+ into the SR by SERCA2, suggesting its potential in preventing arrhythmias.
Smiles
OC1(CCCCN(CCCCN2CC3=CC(OC)=CC=C3SCC2)CCCCC4(O)CC4)CC1
Molecular Formula
C28H46N2O3S
Molecular Weight
490.74
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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