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RyR2 stabilizer-1

CAT: 0931-T208241-01Size: 10 mgDry Ice: NoHazardous: No
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CAT#:0931-T208241-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3012675-16-7
Target
Calcium Channel
Related Pathways
Membrane transporter/Ion channel, Metabolism
Bioactivity
RyR2 stabilizer-1 (Compound12a) is a potent stabilizer of RyR2 and an activator of SERCA2a, with EC50 values of 2.7 μM for RyR2 and 383 nM for SERCA2. This compound inhibits the leakage of Ca2+ through SR RyR2 while promoting the reuptake of Ca2+ into the SR by SERCA2, suggesting its potential in preventing arrhythmias.
Smiles
OC1(CCCCN(CCCCN2CC3=CC(OC)=CC=C3SCC2)CCCCC4(O)CC4)CC1
Molecular Formula
C28H46N2O3S
Molecular Weight
490.74
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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