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Microtubule stabilizer-1

CAT: 0804-HY-176540-01Size: 5 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-176540-01Size:5 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Microtubule stabilizer-1 (compound 69) is a brain-penetrant microtubule (MT) stabilizer. Microtubule stabilizer-1 increases acetylated α-tubulin (AcTub) levels and prevents the characteristic loss of neuronal MTs that is observed after incubation with Okadaic acid. Microtubule stabilizer-1 can be used for the study of Alzheimer’s disease (AD) and related neurodegenerative tauopathies[1].
CAS Number
2699937-76-1
UNSPSC
12352005
Target
Microtubule/Tubulin
Related Pathways
Cell Cycle/DNA Damage; Cytoskeleton
Field of Research
Neurological Disease
Purity
99.47
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CC(C)(C)[C@@H](C)NC1=C(C2=C(C=C(C=C2F)C#N)F)C(Cl)=NC3=NC=NN31
Molecular Formula
C18H17ClF2N6
Molecular Weight
390.82
References & Citations
[1]Oukoloff K, et al. Evaluation of the Structure-Activity Relationship of Microtubule-Targeting 1,2,4-Triazolo[1,5-a]pyrimidines Identifies New Candidates for Neurodegenerative Tauopathies. J Med Chem. 2021 Jan 28;64 (2) :1073-1102.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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