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LC kinetic stabilizer-1

CAT: 0804-HY-145889Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-145889Size:1 Each
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Description
LC kinetic stabilizer-1 (compound 21) is a potent and selective amyloidogenic immunoglobulin light chain kinetic stabilizer with EC50s of 140 and 74.1 nM for WIL-FL* and WIL-FL* T46L/F49Y, respectively. WIL-FL is an amyloidogenic FL LC dimer[1].
CAS Number
2495750-19-9
UNSPSC
12352005
Target
Biochemical Assay Reagents
Type
Reference compound
Related Pathways
Others
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/lc-kinetic-stabilizer-1.html
Solubility
10 mM in DMSO
Smiles
O=C1OC2=CC(N(CC)CC)=CC=C2C(C)=C1CCNC(NCC3=CC(C4=CNC=N4)=CC=C3)=O
Molecular Formula
C27H31N5O3
Molecular Weight
473.57
References & Citations
[1]Yan NL, et al. Amyloidogenic immunoglobulin light chain kinetic stabilizers comprising a simple urea linker module reveal a novel binding sub-site. Bioorg Med Chem Lett. 2022;60:128571.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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