PVD-06

CAT: 0931-T208238-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0931-T208238-01Size:10 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
3032975-48-4
Target
PROTACs|||Phosphatase
Related Pathways
PROTAC|||Metabolism
Bioactivity
PVD-06 is a selective PROTAC-based degrader of PTPN2 (with a selectivity index of greater than 60-fold over PTP1B) and exhibits anticancer activity. It induces the degradation of PTPN2 through ubiquitination and proteasome-dependent pathways. PVD-06 also enhances T cell activation and amplifies IFN-?-mediated cytotoxicity.
Smiles
C(C(O)=O)(F)(F)F.FC=1C2=C(C=C(O)C1N3S(=O)(=O)NC(=O)C3)C=CC(=C2)C4=CN(CC(NCCCCCC(N[C@H](C(=O)N5[C@H](C(N[C@@H](C)C6=CC=C(C=C6)C7=C(C)N=CS7)=O)C[C@@H](O)C5)[C@](C)(C)C)=O)=O)N=C4
Molecular Formula
C48H55F4N9O11S2
Molecular Weight
1074.13
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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