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PI3Kδ-IN-17

CAT: 0804-HY-149634Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-149634Size:1 Each
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Description
PI3Kδ-IN-17 (Compound S5) is a potent inhibitor of PI3Kδ, with IC50 of 2.82 nM. PI3Kδ-IN-17 shows strong inhibitory activity of proliferation in SU-DHL-6 cells (IC50=0.035 μM) [1].
CAS Number
2768181-63-9
UNSPSC
12352005
Target
PI3K
Type
Reference compound
Related Pathways
PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pi3kδ-in-17.html
Solubility
10 mM in DMSO
Smiles
O=C(N1C[C@@H](NC2=C3C(C=CC(C4=CC(C(F)(F)F)=C(OC)N=C4)=N3)=NC=N2)CC1)[C@H]5NCCC5
Molecular Formula
C23H24F3N7O2
Molecular Weight
487.48
References & Citations
[1]Huanrong Bai, et al. Discovery of novel pyrido[3,2-d]pyrimidine derivatives as selective and potent PI3Kδ inhibitors. Drug Dev Res. 2023 Sep 21.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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