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HDAC6-IN-17

CAT: 0804-HY-149372Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-149372Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
HDAC6-IN-17 (compound 5b) is a potent HDAC6 inhibitor with IC50 values of 150 nM, 1400 nM, and 2300 nM for HDAC6, HDAC8, and HDAC4, respectively. HDAC6-IN-17 has cytotoxic activity on human cancer cell lines. HDAC6-IN-17 can be used in research of cancer[1].
UNSPSC
12352005
Target
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/hdac6-in-17.html
Solubility
10 mM in DMSO
Smiles
O=C(NO)C1=CC=C(CSC(N2C3=CC=CC=C3)=NC4=C(C=CC=C4)C2=O)C=C1
Molecular Formula
C22H17N3O3S
Molecular Weight
403.45
References & Citations
[1]Khetmalis YM, et, al. Design, Synthesis, and Biological Evaluation of Novel Quinazolin-4 (3H) -One-Based Histone Deacetylase 6 (HDAC6) Inhibitors for Anticancer Activity. Int J Mol Sci. 2023 Jul 3;24 (13) :11044.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
HDAC4; HDAC6; HDAC8

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