BO-1

• Description:

  BO-1 is a benzoate ester with antibacterial activity. BO-1 inhibits multidrug-resistant Staphylococcus aureus, and acts function synergistically with antibiotic, such as Ciprofloxacin (HY-B0356) . BO-1 can reverse the resistance of antibiotic-resistant S. aureus strains, and decreases the level of inflammatory factors IL-6 and C-reactive protein in vivo in mice[1].

• UNSPSC:

  12352005

• Target:

  Bacterial

• Type:

  Reference compound

• Related Pathways:

  Anti-infection

• Applications:

  COVID-19-immunoregulation

• Field of Research:

  Infection

• Assay Protocol:

  https://www.medchemexpress.com/bo-1.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O[C@]1 (COC (C2=CC=CC=C2) =O) [C@H] (Cl) C=C[C@@H] (OC (C3=CC=CC=C3) =O) [C@@H]1O

• Molecular Formula:

  C21H19ClO6

• Molecular Weight:

  402.82

• References & Citations:

  [1]Xiao CY, et al. Natural Product BO-1 as an Inner Responsive Molecule Inhibits Antimicrobial-Resistant Staphylococcus aureus via Synergism. ACS Infect Dis. 2023 Aug 11;9 (8) :1523-1533.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported