BO-1

• Description :

  BO-1 is a benzoate ester with antibacterial activity. BO-1 inhibits multidrug-resistant Staphylococcus aureus, and acts function synergistically with antibiotic, such as Ciprofloxacin (HY-B0356) . BO-1 can reverse the resistance of antibiotic-resistant S. aureus strains, and decreases the level of inflammatory factors IL-6 and C-reactive protein in vivo in mice[1].

• UNSPSC :

  12352005

• Target :

  Bacterial

• Type :

  Reference compound

• Related Pathways :

  Anti-infection

• Applications :

  COVID-19-immunoregulation

• Field of Research :

  Infection

• Assay Protocol :

  https://www.medchemexpress.com/bo-1.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O[C@]1(COC(C2=CC=CC=C2)=O)[C@H](Cl)C=C[C@@H](OC(C3=CC=CC=C3)=O)[C@@H]1O

• Molecular Formula :

  C21H19ClO6

• Molecular Weight :

  402.82

• References & Citations :

  [1]Xiao CY, et al. Natural Product BO-1 as an Inner Responsive Molecule Inhibits Antimicrobial-Resistant Staphylococcus aureus via Synergism. ACS Infect Dis. 2023 Aug 11;9 (8) :1523-1533.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported