(-) -BO 2367

• Description:

  (-) -BO 2367, an antimicrobial quinolone, is a strong mammalian and bacterial topoisomerase II inhibitor. (-) -BO 2367 shows IC50 values with 3.8 μM, 0.5 μM, and 1 μM against the DNA relaxation activity of L1210 topoisomerase II and the supercoiling activities of Escherichia coli gyrase and Micrococcus luteus gyrase, respectively. (-) -BO 2367 is a potent antitumor agent[1].

• UNSPSC:

  12352005

• Target:

  Bacterial; Topoisomerase

• Type:

  Reference compound

• Related Pathways:

  Anti-infection; Cell Cycle/DNA Damage

• Field of Research:

  Cancer; Inflammation/Immunology

• Assay Protocol:

  https://www.medchemexpress.com/minus-bo-2367.html

• Smiles:

  FC1=C2N(C3CC3)C=C(C(C2=CC(F)=C1N4C[C@@]5([H])[C@@](CC=C[C@H]5N)([H])C4)=O)C(O)=O.Cl

• Molecular Formula:

  C21H22ClF2N3O3

• Molecular Weight:

  437.87

• References & Citations:

  [1]T Yoshinari, et al. Stereo (C7) -dependent topoisomerase II inhibition and tumor growth suppression by a new quinolone, BO-2367. Jpn J Cancer Res. 1993 Jul;84 (7) :800-6.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  Topo II

• CAS Number:

  [145902-81-4]