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(-) -BO 2367

CAT: 0804-HY-117657Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-117657Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
(-) -BO 2367, an antimicrobial quinolone, is a strong mammalian and bacterial topoisomerase II inhibitor. (-) -BO 2367 shows IC50 values with 3.8 μM, 0.5 μM, and 1 μM against the DNA relaxation activity of L1210 topoisomerase II and the supercoiling activities of Escherichia coli gyrase and Micrococcus luteus gyrase, respectively. (-) -BO 2367 is a potent antitumor agent[1].
CAS Number
145902-81-4
UNSPSC
12352005
Target
Bacterial; Topoisomerase
Type
Reference compound
Related Pathways
Anti-infection; Cell Cycle/DNA Damage
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/minus-bo-2367.html
Smiles
FC1=C2N(C3CC3)C=C(C(C2=CC(F)=C1N4C[C@@]5([H])[C@@](CC=C[C@H]5N)([H])C4)=O)C(O)=O.Cl
Molecular Formula
C21H22ClF2N3O3
Molecular Weight
437.87
References & Citations
[1]T Yoshinari, et al. Stereo (C7) -dependent topoisomerase II inhibition and tumor growth suppression by a new quinolone, BO-2367. Jpn J Cancer Res. 1993 Jul;84 (7) :800-6.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Topo II

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