MPX-004

• Description:

  MPX-004 is a potent GluN2A antagonist. MPX-004 inhibits GluN2A-containing NMDA receptors expressed in HEK cells with an IC50 of 79 nM. MPX-004 has no inhibitory effect on GluN2B or GluN2D receptor-mediated responses. MPX-004 has the potential for neuropsychiatric and developmental disorders research[1].

• UNSPSC:

  12352005

• Target:

  IGluR

• Type:

  Reference compound

• Related Pathways:

  Membrane Transporter/Ion Channel; Neuronal Signaling

• Applications:

  Neuroscience-Neurodegeneration

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/mpx-004.html

• Purity:

  99.58

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(C1=NC=C(CNS(=O)(C2=CC=C(C(Cl)=C2)F)=O)N=C1)NCC3=CN=C(C)S3

• Molecular Formula:

  C17H15ClFN5O3S2

• Molecular Weight:

  455.91

• References & Citations:

  [1]Robert A Volkmann, et al. MPX-004 and MPX-007: New Pharmacological Tools to Study the Physiology of NMDA Receptors Containing the GluN2A Subunit. PLoS One. 2016 Feb 1;11 (2) :e0148129.

• Shipping Conditions:

  Room Temperature

• Storage Conditions:

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  5-HT1 Receptor; NMDA Receptor

• CAS Number:

  [1688684-07-2]