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ELP-004

CAT: 0804-HY-W641445-01Size: 10 mgDry Ice: NoHazardous: No
CAT#:0804-HY-W641445-01Size:10 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
ELP-004 is a TRPC channel inhibitor and inhibtis TRPC channel-mediated Ca2+ entry. ELP-004 is an osteoclast inhibitor and inhibits osteoclast differentiation. ELP-004 inhibits basal Ca2+ and related NFATc1 translocation in inflammatory osteoclastogenesis. ELP-004 reduces bone erosion in a mouse model of rheumatoid arthritis[1][2].
CAS Number
[15533-81-0]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
TRP Channel
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Inflammation/Immunology
Concentration
10mM
Purity
99.89
Solubility
DMSO : 50 mg/mL (ultrasonic)
Smiles
CCC(N(C1=CC(Cl)=C(C=C1)Cl)C)=O
Molecular Formula
C10H11Cl2NO
Molecular Weight
232.11
Precautions
H302, H315, H319, H335
References & Citations
[1]Ray S, et al. Targeting TRPC channels for control of arthritis-induced bone erosion. Sci Adv. 2025 Jan 17;11 (3) :eabm9843.|[2]McCall JL, et al. Preclinical evaluation of ELP-004 in mice. Pharmacol Res Perspect. 2024 Aug;12 (4) :e1230.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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