TP-004

• Description :

  TP-004, a chemical probe, is a potent and reversible inhibitor of methionine aminopeptidase 2 (MetAP2), with an IC50 of 6 nM[1].

• UNSPSC :

  12352005

• Target :

  MetAP

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Metabolism-protein/nucleotide metabolism

• Field of Research :

  Metabolic Disease

• Assay Protocol :

  https://www.medchemexpress.com/tp-004.html

• Concentration :

  10mM

• Purity :

  99.17

• Solubility :

  DMSO : 250 mg/mL (ultrasonic)

• Smiles :

  O[C@H]1CN(C2=NC=C(C3=CC(C(F)(F)F)=CC4=C3C=NN4)C(C)=N2)CC1

• Molecular Formula :

  C17H16F3N5O

• Molecular Weight :

  363.34

• References & Citations :

  [1]Cheruvallath, Z., et al. Discovery of potent, reversible MetAP2 inhibitors via fragment based drug discovery and structure based drug design—Part 1. Bioorganic & Medicinal Chemistry Letters, 26 (12), 2774–2778.

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [1454299-21-8]