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BTK-IN-22

CAT: 0804-HY-148585Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-148585Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
BTK-IN-22 is a BTK inhibitor (IC50: 0.9 nM). BTK-IN-22 also inhibits BLX and BMX with IC50s of 1.4 and 1.2 nM respectively. BTK-IN-22 shows improved kinase selectivity compared to Ibrutinib
CAS Number
2573048-10-7
UNSPSC
12352005
Target
Btk
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/btk-in-22.html
Solubility
10 mM in DMSO
Smiles
C=CC(N1CCC[C@@H](C1)N2N=C(C3=C(N=CN=C32)N)C4=CC=C(C=C4C)OC5=CC=CC=C5)=O
Molecular Formula
C26H26N6O2
Molecular Weight
454.52
References & Citations
[1]Sean T. Toenjes, et al. Controlling Ibrutinib’s Conformations about Its Heterobiaryl Axis to Increase BTK Selectivity. ACS Med. Chem. Lett. 2023. https://doi.org/10.1021/acsmedchemlett.2c00523
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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