PDE5-IN-42

• Description :

  PDE5-IN-42 (Compound 42) is a potent and orally active PDE5 inhibitor with an IC50 of 0.04 nM. PDE5-IN-42 maintains selectivity over PDE6 and PDE11[1].

• UNSPSC :

  12352005

• Hazard Statement :

  H302-H315-H319-H335

• Target :

  Phosphodiesterase (PDE)

• Type :

  Reference compound

• Related Pathways :

  Metabolic Enzyme/Protease

• Applications :

  Neuroscience-Neuromodulation

• Field of Research :

  Cardiovascular Disease

• Assay Protocol :

  https://www.medchemexpress.com/pde5-in-42.html

• Solubility :

  10 mM in DMSO

• Smiles :

  O=C(C1CCN(C2=NC(NC3=NC=CC(C)=C3)=C(N(CCOCC)N=C4CC)C4=N2)CC1)O

• Molecular Formula :

  C23H31N7O3

• Molecular Weight :

  453.54

• Precautions :

  P261-P280-P302+P352

• References & Citations :

  [1]Tollefson MB, et al. 1- (2-Ethoxyethyl) -1H-pyrazolo[4,3-d]pyrimidines as potent phosphodiesterase 5 (PDE5) inhibitors. Bioorg Med Chem Lett. 2010 May 15;20 (10) :3120-4.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• CAS Number :

  [936449-28-4]