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PDE5-IN-42

CAT: 0804-HY-128060Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-128060Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PDE5-IN-42 (Compound 42) is a potent and orally active PDE5 inhibitor with an IC50 of 0.04 nM. PDE5-IN-42 maintains selectivity over PDE6 and PDE11[1].
CAS Number
936449-28-4
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/pde5-in-42.html
Solubility
10 mM in DMSO
Smiles
O=C(C1CCN(C2=NC(NC3=NC=CC(C)=C3)=C(N(CCOCC)N=C4CC)C4=N2)CC1)O
Molecular Formula
C23H31N7O3
Molecular Weight
453.54
Precautions
P261-P280-P302+P352
References & Citations
[1]Tollefson MB, et al. 1- (2-Ethoxyethyl) -1H-pyrazolo[4,3-d]pyrimidines as potent phosphodiesterase 5 (PDE5) inhibitors. Bioorg Med Chem Lett. 2010 May 15;20 (10) :3120-4.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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