PI3Kα-IN-8

PI3Kα-IN-8

• CAS Number: 2315320-24-0
• UNSPSC Description: PI3Kα-IN-8 (Compound 9g) is a selective PI3Kα inhibitor with an IC50 of 0.012 μM. PI3Kα-IN-8 increases intracellular reactive oxygen species level, decreases mitochondrial membrane potential and induces apoptosis[1].
• Target Antigen: Apoptosis; PI3K; Reactive Oxygen Species
• Type: Reference compound
• Related Pathways: Apoptosis;Immunology/Inflammation;Metabolic Enzyme/Protease;NF-κB;PI3K/Akt/mTOR
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/pi3kα-in-8.html
• Solubility: 10 mM in DMSO
• Smiles: C[C@@]12C3=CC(Br)=C(N=C(N4)NC5=CC=C(C=C5)C#N)C4=C3CC[C@@]1([H])[C@@](C)(CCC2)C(OC)=O
• Molecular Weight: 507.42
• References & Citations: [1]Yang YQ, et al. Synthesis and anticancer evaluation of novel 1H-benzo[d]imidazole derivatives of dehydroabietic acid as PI3Kα inhibitors. Bioorg Chem. 2020 Jul;100:103845.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported