CDK9-IN-24

CAT: 0804-HY-155153Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-155153Size:1 Each
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CDK9-IN-24 (compound 21a) is a highly selective CDK9 inhibitor with significant inhibitory effect on tumor growth. CDK9-IN-24 effectively blocks cell proliferation and induces apoptosis by downregulating Mcl-1 and c-Myc, and can be used in acute myeloid leukemia research[1].
UNSPSC
12352005
Target
Apoptosis; CDK
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/cdk9-in-24.html
Solubility
10 mM in DMSO
Smiles
CN(CC1)CC=C1C2=C3C(C(C=C(C4=CC=C(N5CCN(C)CC5)C=C4)O3)=O)=C(O)C=C2OC
Molecular Formula
C27H31N3O4
Molecular Weight
461.55
References & Citations
[1]Wu T, et al. Design and optimization of selective and potent CDK9 inhibitors with flavonoid scaffold for the treatment of acute myeloid leukemia. Eur J Med Chem. 2023 Nov 5;259:115711.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
CDK9

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