KDM1/CDK1-IN-1

CAT: 0931-T62405-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0931-T62405-01Size:25 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

Quick Request Actions

Target

Others, Caspase, Apoptosis, Histone Demethylase, CDK

Related Pathways

Apoptosis, Proteases/Proteasome, Cell Cycle/Checkpoint, Others, Chromatin/Epigenetic

Bioactivity

KDM1/CDK1-IN-1 (compound 4) is a potent inhibitor of KDM1 (IC50: 0.096 μM) and CDK1 (IC50: 0.078 μM), blocking the cell cycle of HOP-92 cells in the G2/M phase and inducing apoptosis. It is highly cytotoxic to CCRF-CEM cells (IC50: 16.34 μM), HOP-92 cells (IC50: 3.45 μM), and Hep-G2 cells (IC50: 7.79 μM) .

Molecular Formula

C22H17N5O3S

Molecular Weight

431.47

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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