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CDK1/2/4-IN-1

CAT: 0804-HY-146253Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-146253Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
CDK1/2/4-IN-1 (compound 3a) is a potent CDK inhibitor with IC50 values of 1.47, 0.78 and 0.87 μM for CDK1, CDK2 and CDK4, respectively. CDK1/2/4-IN-1 arrests cell cycle at G2/M phase and induces apoptosis. CDK1/2/4-IN-1 elevates Bax, caspase-3, P53 levels and decreases Bcl-2 level. CDK1/2/4-IN-1 can be used for cancer research[1].
CAS Number
2414633-49-9
UNSPSC
12352005
Target
Apoptosis; Bcl-2 Family; Caspase; CDK
Type
Reference compound
Related Pathways
Apoptosis; Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cdk1-2-4-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=C(C)SC(NC)=N1)/C=C/C2=CC=C(OC)C=C2
Molecular Formula
C15H16N2O2S
Molecular Weight
288.36
References & Citations
[1]Farghaly TA, et, al. Discovery of thiazole-based-chalcones and 4-hetarylthiazoles as potent anticancer agents: Synthesis, docking study and anticancer activity. Bioorg Chem. 2020 May;98:103761.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Bax; Bcl-2; Caspase 3; CDK1; CDK2; CDK4

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