CDK1/2/4-IN-1
CAT:
804-HY-146253
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- Availability: 24/48H Stock Items & 2 to 6 Weeks non Stock Items.
- Dry Ice Shipment: No
CDK1/2/4-IN-1
- CAS Number: 2414633-49-9
- UNSPSC Description: CDK1/2/4-IN-1 (compound 3a) is a potent CDK inhibitor with IC50 values of 1.47, 0.78 and 0.87 μM for CDK1, CDK2 and CDK4, respectively. CDK1/2/4-IN-1 arrests cell cycle at G2/M phase and induces apoptosis. CDK1/2/4-IN-1 elevates Bax, caspase-3, P53 levels and decreases Bcl-2 level. CDK1/2/4-IN-1 can be used for cancer research[1].
- Target Antigen: Apoptosis; Bcl-2 Family; Caspase; CDK
- Type: Reference compound
- Related Pathways: Apoptosis;Cell Cycle/DNA Damage
- Applications: Cancer-Kinase/protease
- Field of Research: Cancer
- Assay Protocol: https://www.medchemexpress.com/cdk1-2-4-in-1.html
- Solubility: 10 mM in DMSO
- Smiles: O=C(C1=C(C)SC(NC)=N1)/C=C/C2=CC=C(OC)C=C2
- Molecular Weight: 288.36
- References & Citations: [1]Farghaly TA, et, al. Discovery of thiazole-based-chalcones and 4-hetarylthiazoles as potent anticancer agents: Synthesis, docking study and anticancer activity. Bioorg Chem. 2020 May;98:103761.
- Shipping Conditions: Room temperature
- Clinical Information: No Development Reported