CDK1/2/4-IN-1

CDK1/2/4-IN-1

• CAS Number: 2414633-49-9
• UNSPSC Description: CDK1/2/4-IN-1 (compound 3a) is a potent CDK inhibitor with IC50 values of 1.47, 0.78 and 0.87 μM for CDK1, CDK2 and CDK4, respectively. CDK1/2/4-IN-1 arrests cell cycle at G2/M phase and induces apoptosis. CDK1/2/4-IN-1 elevates Bax, caspase-3, P53 levels and decreases Bcl-2 level. CDK1/2/4-IN-1 can be used for cancer research[1].
• Target Antigen: Apoptosis; Bcl-2 Family; Caspase; CDK
• Type: Reference compound
• Related Pathways: Apoptosis;Cell Cycle/DNA Damage
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/cdk1-2-4-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: O=C(C1=C(C)SC(NC)=N1)/C=C/C2=CC=C(OC)C=C2
• Molecular Weight: 288.36
• References & Citations: [1]Farghaly TA, et, al. Discovery of thiazole-based-chalcones and 4-hetarylthiazoles as potent anticancer agents: Synthesis, docking study and anticancer activity. Bioorg Chem. 2020 May;98:103761.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported