PI3K-IN-35

PI3K-IN-35

• CAS Number: 2458163-99-8
• UNSPSC Description: PI3K-IN-35 (Compound 6l) is a highly selective PI3K inhibitor with IC50 values of 13.98, 7.22 and 10.94 μM for PI3K-α、PI3K-β and PI3K-δ, respectively. PI3K-IN-35 arrests cell cycle at G2/M phase and induces apoptosis. PI3K-IN-35 can be used in leukemia research[1].
• Target Antigen: Apoptosis; PI3K
• Type: Reference compound
• Related Pathways: Apoptosis;PI3K/Akt/mTOR
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/pi3k-in-35.html
• Solubility: 10 mM in DMSO
• Smiles: COC(C=C1)=CC=C1C2=NC(N/N=C/C3=CNC4=C3C=CC=C4)=NC(N5CCOCC5)=C2C#N
• Molecular Weight: 453.50
• References & Citations: [1]Helwa AA, et al. Novel antiproliferative agents bearing morpholinopyrimidine scaffold as PI3K inhibitors and apoptosis inducers; design, synthesis and molecular docking. Bioorg Chem. 2020 Sep;102:104051.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported