PI3K-IN-33

• Description :

  PI3K-IN-33 (Compound 6e) is a highly selective PI3K inhibitor with IC50 values of 11.73, 6.09 and 11.18 μM for PI3K-α、PI3K-β and PI3K-δ , respectively. PI3K-IN-33 arrests cell cycle at G2/M phase and induces apoptosis. PI3K-IN-33 can be used in leukemia research[1].

• UNSPSC :

  12352005

• Target :

  Apoptosis; PI3K

• Type :

  Reference compound

• Related Pathways :

  Apoptosis; PI3K/Akt/mTOR

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/pi3k-in-33.html

• Solubility :

  10 mM in DMSO

• Smiles :

  BrC1=CC(/C=N/NC2=NC(N3CCOCC3)=C(C(C4=CC=C(C=C4)OC)=N2)C#N)=CC=C1

• Molecular Formula :

  C23H21BrN6O2

• Molecular Weight :

  493.36

• References & Citations :

  [1]Helwa AA, et al. Novel antiproliferative agents bearing morpholinopyrimidine scaffold as PI3K inhibitors and apoptosis inducers; design, synthesis and molecular docking. Bioorg Chem. 2020 Sep;102:104051.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  PI3Kα; PI3Kβ; PI3Kδ

• CAS Number :

  [2458163-92-1]