C-Fms-IN-12

CAT: 0804-HY-147864Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-147864Size:1 Each

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Description

C-Fms-IN-12 (Compound 4g) is an FMS kinase inhibitor. c-Fms-IN-12 can also inhibits c-KIT. c-Fms-IN-12 is a potential broad-spectrum anticancer agent against multiple cancer types. c-Fms-IN-12 induces A549 cell apoptosis[1].

CAS Number

2145102-33-4

UNSPSC

12352005

Target

Apoptosis; c-Fms; c-Kit

Type

Reference compound

Related Pathways

Apoptosis; Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/c-fms-in-12-1.html

Solubility

10 mM in DMSO

Smiles

O=C(NC1=CN=C(NC2=CC=C(N3CCOCC3)C=C2)N=C1OC4=CC=CC(OC)=C4)NC5=CC(OC)=CC(OC)=C5

Molecular Formula

C30H32N6O6

Molecular Weight

572.61

References & Citations

[1]Farag AK, et al. Diarylurea derivatives comprising 2,4-diarylpyrimidines: Discovery of novel potential anticancer agents via combined failed-ligands repurposing and molecular hybridization approaches. Bioorg Chem. 2020 Oct;103:104121.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Chemical Information

1-(3,5-Dimethoxyphenyl)-3-[4-(3-methoxyphenoxy)-2-(4-morpholin-4-ylanilino)pyrimidin-5-yl]urea

CAS Number	2145102-33-4
PubChem CID	142749657
IUPAC Name	1-(3,5-dimethoxyphenyl)-3-[4-(3-methoxyphenoxy)-2-(4-morpholin-4-ylanilino)pyrimidin-5-yl]urea
Molecular Formula	C30H32N6O6
Molecular Weight	572.6
XLogP	4.2
Topological Polar Surface Area	128
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	10
Heavy Atom Count	42
Formal Charge	0
Complexity	801

SMILES

COC1=CC(=CC=C1)OC2=NC(=NC=C2NC(=O)NC3=CC(=CC(=C3)OC)OC)NC4=CC=C(C=C4)N5CCOCC5

InChI

InChI=1S/C30H32N6O6/c1-38-23-5-4-6-24(17-23)42-28-27(34-30(37)33-21-15-25(39-2)18-26(16-21)40-3)19-31-29(35-28)32-20-7-9-22(10-8-20)36-11-13-41-14-12-36/h4-10,15-19H,11-14H2,1-3H3,(H,31,32,35)(H2,33,34,37)

InChIKey

SBLCNWNDMUJOKH-UHFFFAOYSA-N

Chemical Structure

2D Structure

CAS: 2145102-33-4

CID: 142749657

Formula: C30H32N6O6

MW: 572.6

Interactive 3D Structure

Loading 3D structure...

View on PubChem Raw 3D data

Computed Properties

Property	Value
Molecular Weight	572.6
XLogP3	4.2
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	10
Exact Mass	572.23833276
Monoisotopic Mass	572.23833276
Topological Polar Surface Area	128 Å²
Heavy Atom Count	42
Formal Charge	0
Complexity	801
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently-Bonded Unit Count	1
Compound Is Canonicalized	Yes

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BA8846-5	c-Fms-IN-12
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M35575-01	C-Fms-IN-13
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T10649-01	C-Fms-IN-3
386597	C-Fms discontinued
MBS3614754-01	c-Fms-IN-2
MBS3845480-01	c-Fms-IN-1
MBS3843871-01	c-Fms-IN-6
MBS3840798-01	c-FMS inhibitor

C-Fms-IN-12

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