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C-Fms-IN-7

CAT: 0804-HY-111948Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-111948Size:1 Each
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Description
C-Fms-IN-7 is a cFMS inhibitor extracted from patent WO2011079076A1, example159, has an IC50 of 18.5 nM[1].
CAS Number
1313408-89-7
UNSPSC
12352005
Target
C-Fms
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
COVID-19-immunoregulation
Field of Research
Cancer; Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/c-fms-in-7.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CN=C2C=C(SC)C=CN21)NC3=CC=CC4=C3C(C5CC5)=NN4CC6=NC(C)=CC=C6
Molecular Formula
C26H24N6OS
Molecular Weight
468.57
References & Citations
[1]Mark Laurence Boys, et al. Substituted n- (1h-indazol-4-yl) imidazo[1, 2-a]pyridine-3- carboxamide compounds as cfms inhibitors. WO2011079076A1
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

c-Fms-IN-7
CAS Number1313408-89-7
PubChem CID67260931
IUPAC NameN-[3-cyclopropyl-1-[(6-methyl-2-pyridinyl)methyl]indazol-4-yl]-7-methylsulfanylimidazo[1,2-a]pyridine-3-carboxamide
Molecular FormulaC26H24N6OS
Molecular Weight468.6
XLogP4.6
Topological Polar Surface Area102
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Heavy Atom Count34
Formal Charge0
Complexity736
SMILES
CC1=NC(=CC=C1)CN2C3=CC=CC(=C3C(=N2)C4CC4)NC(=O)C5=CN=C6N5C=CC(=C6)SC
InChI
InChI=1S/C26H24N6OS/c1-16-5-3-6-18(28-16)15-32-21-8-4-7-20(24(21)25(30-32)17-9-10-17)29-26(33)22-14-27-23-13-19(34-2)11-12-31(22)23/h3-8,11-14,17H,9-10,15H2,1-2H3,(H,29,33)
InChIKey
FTZFXXAIYXWZLT-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of c-Fms-IN-7
CAS: 1313408-89-7
CID: 67260931
Formula: C26H24N6OS
MW: 468.6
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight468.6
XLogP34.6
Hydrogen Bond Donor Count1
Hydrogen Bond Acceptor Count5
Rotatable Bond Count6
Exact Mass468.17323058
Monoisotopic Mass468.17323058
Topological Polar Surface Area102 Ų
Heavy Atom Count34
Formal Charge0
Complexity736
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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