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Nampt-IN-8

CAT: 0804-HY-147795Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-147795Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
Nampt-IN-8 (Compound 10d) is an NAMPT inhibitor with an IC50 of 0.183 μM. Nampt-IN-8 is also a relatively good NQO1 substrate. Nampt-IN-8 induces cell apoptosis and ROS[1].
CAS Number
2453183-75-8
UNSPSC
12352005
Target
Apoptosis; NAMPT; Quinone Reductase; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nampt-in-8.html
Solubility
10 mM in DMSO
Smiles
O=C1C2=C(CCCC3(C)C)C3=CC=C2C4=C(C1=O)C(C)=C(O4)CNC5=CC=C(C=C5)CCNC(/C=C/C6=CN=CC=C6)=O
Molecular Formula
C36H35N3O4
Molecular Weight
573.68
References & Citations
[1]Zhang K, et al. Discovery of Small Molecules Simultaneously Targeting NAD (P) H:Quinone Oxidoreductase 1 and Nicotinamide Phosphoribosyltransferase: Treatment of Drug-Resistant Non-small-Cell Lung Cancer. J Med Chem. 2022 Jun 9;65 (11) :7746-7769.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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