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PI3Kα-IN-6

CAT: 0804-HY-147767Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-147767Size:1 Each
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Description
PI3Kα-IN-6 (Compound 5b) is a PI3Kα inhibitor. PI3Kα-IN-6 exhibits anticancer potential and no toxicity in normal cells. PI3Kα-IN-6 increases generation of ROS, reduces mitochondrial membrane potential (MMP) and induces apoptosis[1].
CAS Number
2272894-14-9
UNSPSC
12352005
Target
Apoptosis; PI3K; Reactive Oxygen Species (ROS)
Type
Reference compound
Related Pathways
Apoptosis; Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pi3kα-in-6.html
Solubility
10 mM in DMSO
Smiles
COC1=CC=C(C=C1)SCC2=C(N=C3C=CC(C)=CN32)I
Molecular Formula
C16H15IN2OS
Molecular Weight
410.27
References & Citations
[1]Singh D, et al. Synthesis of 3-N-/O-/S-methyl-imidazo[1,2-a] pyridine derivatives for caspase-3 mediated apoptosis induced anticancer activity.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PI3Kα

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