HDAC6-IN-9

• Description:

  HDAC6-IN-9 (compound 12c) is a potent and selective HDAC6 inhibitor with IC50 values of 11.8, 15.2, 4.2, 139.6, 21.3 nM for HDAC1, HDAC3, HDAC6, HDAC8, HDAC10, respectively. HDAC6-IN-9 shows anti-proliferative activities[1].

• UNSPSC:

  12352005

• Target:

  HDAC

• Type:

  Reference compound

• Related Pathways:

  Cell Cycle/DNA Damage; Epigenetics

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/hdac6-in-9.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C(NC1=CC=C2C=CC=CC2=C1)CC3=CC=C(C=C3)C(NO)=O

• Molecular Formula:

  C19H16N2O3

• Molecular Weight:

  320.34

• References & Citations:

  [1]Li X, et al. Design, Synthesis, and biological evaluation of HDAC6 inhibitors based on Cap modification strategy. Bioorg Chem. 2022 Aug;125:105874.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• Isoform:

  HDAC1; HDAC10; HDAC3; HDAC6; HDAC8

• CAS Number:

  2796282-58-9