FGFR3-IN-3

• Description :

  FGFR3-IN-3 (compound 40a) is a potent and pan-FGFR inhibitor, with IC50s of 2.1 nM, 3.1 nM, 4.3 nM and 74 nM for FGFR1, 2, 3, and 4, respectively. FGFR3-IN-3 can be used for the research of bladder cancer[1].

• CAS Number :

  [2428738-41-2]

• UNSPSC :

  12352005

• Target :

  FGFR

• Type :

  Reference compound

• Related Pathways :

  Protein Tyrosine Kinase/RTK

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/fgfr3-in-3.html

• Solubility :

  10 mM in DMSO

• Smiles :

  CCNS(=O)(C1=C(C=CC=C1)NC2=NC(NC3=CC(OC)=C(C=C3)N4CCC(CC4)N5CCN(CC5)C)=NC=C2NC(C6=CC(OC)=CC(OC)=C6)=O)=O

• Molecular Formula :

  C38H49N9O6S

• Molecular Weight :

  759.92

• References & Citations :

  [1]Kuriwaki I, et, al. Structure-based drug design of 1,3,5-triazine and pyrimidine derivatives as novel FGFR3 inhibitors with high selectivity over VEGFR2. Bioorg Med Chem. 2020 May 15;28 (10) :115453.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported