FGFR3-IN-3

CAT: 0804-HY-147715Size: 1 EachDry Ice: NoHazardous: No

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CAT#:0804-HY-147715Size:1 Each

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24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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Description

FGFR3-IN-3 (compound 40a) is a potent and pan-FGFR inhibitor, with IC50s of 2.1 nM, 3.1 nM, 4.3 nM and 74 nM for FGFR1, 2, 3, and 4, respectively. FGFR3-IN-3 can be used for the research of bladder cancer[1].

CAS Number

2428738-41-2

UNSPSC

12352005

Target

FGFR

Type

Reference compound

Related Pathways

Protein Tyrosine Kinase/RTK

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/fgfr3-in-3.html

Solubility

10 mM in DMSO

Smiles

CCNS(=O)(C1=C(C=CC=C1)NC2=NC(NC3=CC(OC)=C(C=C3)N4CCC(CC4)N5CCN(CC5)C)=NC=C2NC(C6=CC(OC)=CC(OC)=C6)=O)=O

Molecular Formula

C38H49N9O6S

Molecular Weight

759.92

References & Citations

[1]Kuriwaki I, et, al. Structure-based drug design of 1,3,5-triazine and pyrimidine derivatives as novel FGFR3 inhibitors with high selectivity over VEGFR2. Bioorg Med Chem. 2020 May 15;28 (10) :115453.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

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BZ66383	PCMV6-FGFR3-3*FLAG
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BA8944-5	FGFR3-IN-5
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T82404-01	FGFR3-IN-7
T73145-01	FGFR3-IN-4
MBS9436223-01	FGFR3 Antibody
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FGFR3-IN-3

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