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FGFR3-IN-1

CAT: 0804-HY-147713Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-147713Size:1 Each
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Description
FGFR3-IN-1 (compound 1) is a fibroblast growth factor receptor (FGFR) inhibitor, with IC50s of 40 nM, 5.1 nM, and 12 nM for FGFR1, 2, and 3, respectively. FGFR3-IN-1 can be used for the research of bladder cancer[1].
CAS Number
2428743-04-6
UNSPSC
12352005
Target
FGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fgfr3-in-1.html
Solubility
10 mM in DMSO
Smiles
CCNS(=O)(C1=CC=CC=C1NC2=NC(NC3=CC(OC)=C(C=C3)N4CCC(CC4)N5CCN(CC5)C)=NC=N2)=O
Molecular Formula
C28H39N9O3S
Molecular Weight
581.73
References & Citations
[1]Kuriwaki I, et, al. Structure-based drug design of 1,3,5-triazine and pyrimidine derivatives as novel FGFR3 inhibitors with high selectivity over VEGFR2. Bioorg Med Chem. 2020 May 15;28 (10) :115453.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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