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FGFR3-IN-5

CAT: 0804-HY-148779-01Size: 1 mgDry Ice: NoHazardous: No
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CAT#:0804-HY-148779-01Size:1 mg
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Description
FGFR3-IN-5 is a potent and selective FGFR3 inhibitor with IC50 values of 3, 44, and 289 nM for FGFR3, FGFR2, and FGFR1, respectively. FGFR3-IN-5 can be used in research of cancer[1].
CAS Number
2446664-72-6
UNSPSC
12352005
Target
FGFR
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/fgfr3-in-5.html
Concentration
10mM
Purity
99.16
Solubility
DMSO : 100 mg/mL (ultrasonic; warming; heat to 160°C)
Smiles
N#CC1=C2C(OC)=CC(C3=CN(C4CCN(CC4)C(C5(CN(C5)C(C=C)=O)F)=O)N=C3)=CN2N=C1
Molecular Formula
C24H24FN7O3
Molecular Weight
477.49
References & Citations
[1]James FB, et, al. Substituted pyrazolo[1,5-a]pyridine compounds as inhibitors of fgfr tyrosine kinases. WO2020131627.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported

Chemical Information

Fgfr3-IN-5
CAS Number2446664-72-6
PubChem CID153619578
IUPAC Name6-[1-[1-(3-fluoro-1-prop-2-enoylazetidine-3-carbonyl)piperidin-4-yl]pyrazol-4-yl]-4-methoxypyrazolo[1,5-a]pyridine-3-carbonitrile
Molecular FormulaC24H24FN7O3
Molecular Weight477.5
XLogP0.7
Topological Polar Surface Area109
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Heavy Atom Count35
Formal Charge0
Complexity895
SMILES
COC1=CC(=CN2C1=C(C=N2)C#N)C3=CN(N=C3)C4CCN(CC4)C(=O)C5(CN(C5)C(=O)C=C)F
InChI
InChI=1S/C24H24FN7O3/c1-3-21(33)30-14-24(25,15-30)23(34)29-6-4-19(5-7-29)31-13-18(11-27-31)16-8-20(35-2)22-17(9-26)10-28-32(22)12-16/h3,8,10-13,19H,1,4-7,14-15H2,2H3
InChIKey
GUEZCEZQFMVREH-UHFFFAOYSA-N
Chemical Structure
2D Structure
2D structure of Fgfr3-IN-5
CAS: 2446664-72-6
CID: 153619578
Formula: C24H24FN7O3
MW: 477.5
Interactive 3D Structure
Loading 3D structure...
View on PubChemRaw 3D data
Computed Properties
PropertyValue
Molecular Weight477.5
XLogP30.7
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count7
Rotatable Bond Count5
Exact Mass477.19246582
Monoisotopic Mass477.19246582
Topological Polar Surface Area109 Ų
Heavy Atom Count35
Formal Charge0
Complexity895
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently-Bonded Unit Count1
Compound Is CanonicalizedYes

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