Levocabastine

CAT: 0804-HY-14277Size: 1 EachDry Ice: NoHazardous: No
CAT#:0804-HY-14277Size:1 Each
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Description
Levocabastine (R 50547) is a potent and selective histamine H1-receptor antagonist. Levocabastine hydrochloride is also a selective, high affinity neurotensin receptor subtype 2 (NTR2) antagonist, with a Ki of 17 nM for mNTR2. Levocabastine can act as a VLA-4 antagonist, interferes with conjunctival eosinophil infiltration in allergic conjunctivitis (AC) [1][2][3].
CAS Number
[79516-68-0]
Product Name Alternative
R 50547
UNSPSC
12352005
Hazard Statement
H302-H312-H332
Target
Histamine Receptor; Integrin; Neurotensin Receptor
Type
Reference compound
Related Pathways
Cytoskeleton; GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Applications
COVID-19-anti-virus
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/levocabastine.html
Solubility
10 mM in DMSO
Smiles
OC([C@@]1(C2=CC=CC=C2)[C@@H](CN([C@]3([H])CC[C@](CC3)(C4=CC=C(C=C4)F)C#N)CC1)C)=O
Molecular Formula
C26H29FN2O2
Molecular Weight
420.52
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501
References & Citations
[1]Folkerts G, et, al. Virus-induced airway hyperresponsiveness in the guinea-pig: possible involvement of histamine and inflammatory cells. Br J Pharmacol. 1993 Apr;108 (4) :1083-93.|[2]Yamauchi R, et, al. Effect of beta-lactotensin on acute stress and fear memory. Peptides. 2006 Dec;27 (12) :3176-82.|[3]Qasem AR, et, al. Contribution of alpha4beta1 integrin to the antiallergic effect of levocabastine. Biochem Pharmacol. 2008 Sep 15;76 (6) :751-62.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Launched
Isoform
H1 Receptor; α4β1

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