Levocabastine

• Description :

  Levocabastine (R 50547) is a potent and selective histamine H1-receptor antagonist. Levocabastine hydrochloride is also a selective, high affinity neurotensin receptor subtype 2 (NTR2) antagonist, with a Ki of 17 nM for mNTR2. Levocabastine can act as a VLA-4 antagonist, interferes with conjunctival eosinophil infiltration in allergic conjunctivitis (AC) [1][2][3].

• CAS Number :

  [79516-68-0]

• Product Name Alternative :

  R 50547

• UNSPSC :

  12352005

• Hazard Statement :

  H302-H312-H332

• Target :

  Histamine Receptor; Integrin; Neurotensin Receptor

• Type :

  Reference compound

• Related Pathways :

  Cytoskeleton; GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling

• Applications :

  COVID-19-anti-virus

• Field of Research :

  Inflammation/Immunology

• Assay Protocol :

  https://www.medchemexpress.com/levocabastine.html

• Solubility :

  10 mM in DMSO

• Smiles :

  OC([C@@]1(C2=CC=CC=C2)[C@@H](CN([C@]3([H])CC[C@](CC3)(C4=CC=C(C=C4)F)C#N)CC1)C)=O

• Molecular Formula :

  C26H29FN2O2

• Molecular Weight :

  420.52

• Precautions :

  P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501

• References & Citations :

  [1]Folkerts G, et, al. Virus-induced airway hyperresponsiveness in the guinea-pig: possible involvement of histamine and inflammatory cells. Br J Pharmacol. 1993 Apr;108 (4) :1083-93.|[2]Yamauchi R, et, al. Effect of beta-lactotensin on acute stress and fear memory. Peptides. 2006 Dec;27 (12) :3176-82.|[3]Qasem AR, et, al. Contribution of alpha4beta1 integrin to the antiallergic effect of levocabastine. Biochem Pharmacol. 2008 Sep 15;76 (6) :751-62.

• Shipping Conditions :

  Room temperature

• Scientific Category :

  Reference compound1

• Clinical Information :

  Launched

• Isoform :

  H1 Receptor; α4β1