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PKC-IN-4

CAT: 0804-HY-147712Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-147712Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PKC-IN-4 (compound 7l) is a potent and orally active aPKC inhibitor with an IC50 of 0.52 μM. PKC-IN-4 inhibits TNF-α induced NF-κB activity in vitro. PKC-IN-4 blocks VEGF- and TNFα-induced permeability across the retinal vasculature[1].
CAS Number
2636771-29-2
UNSPSC
12352005
Target
PKC
Type
Reference compound
Related Pathways
Epigenetics; TGF-beta/Smad
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Assay Protocol
https://www.medchemexpress.com/pkc-in-4.html
Solubility
10 mM in DMSO
Smiles
NCC1CCN(CC1)C2=NC(C3=CC=NC=C3)=NC4=C2C5=C(S4)CCCC5
Molecular Formula
C21H25N5S
Molecular Weight
379.52
References & Citations
[1]Liu X, et al. Synthesis and structure-activity relationships of thieno[2,3-d]pyrimidines as atypical protein kinase C inhibitors to control retinal vascular permeability and cytokine-induced edema. Bioorg Med Chem. 2020 Jun 1;28 (11) :115480.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
PKC

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