PKC-IN-4

PKC-IN-4

• CAS Number: 2636771-29-2
• UNSPSC Description: PKC-IN-4 (compound 7l) is a potent and orally active aPKC inhibitor with an IC50 of 0.52 μM. PKC-IN-4 inhibits TNF-α induced NF-κB activity in vitro. PKC-IN-4 blocks VEGF- and TNFα-induced permeability across the retinal vasculature[1].
• Target Antigen: PKC
• Type: Reference compound
• Related Pathways: Epigenetics;TGF-beta/Smad
• Applications: COVID-19-immunoregulation
• Field of Research: Inflammation/Immunology
• Assay Protocol: https://www.medchemexpress.com/pkc-in-4.html
• Solubility: 10 mM in DMSO
• Smiles: NCC1CCN(CC1)C2=NC(C3=CC=NC=C3)=NC4=C2C5=C(S4)CCCC5
• Molecular Weight: 379.52
• References & Citations: [1]Liu X, et al. Synthesis and structure-activity relationships of thieno[2,3-d]pyrimidines as atypical protein kinase C inhibitors to control retinal vascular permeability and cytokine-induced edema. Bioorg Med Chem. 2020 Jun 1;28(11):115480.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported