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PKC-IN-6

CAT: 0804-HY-W013852-01Size: 25 gDry Ice: NoHazardous: No
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CAT#:0804-HY-W013852-01Size:25 g
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
PKC-IN-6 (Compound 21) is a selective inhibitor of tyrosine and serine kinases. PKC-IN-6 shows inhibitory activity against PKC-α, PKC-δ, PKA, EGF-R with IC50 values of 240, >500, >500, >100 μM, respectively. PKC-IN-6 is promising for research of cancers[1].
CAS Number
152460-10-1
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
EGFR; PKA; PKC; Ser/Thr Kinase; Tyrosinase
Related Pathways
Epigenetics; JAK/STAT Signaling; Metabolic Enzyme/Protease; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt; TGF-beta/Smad
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Concentration
10mM
Purity
99.93
Solubility
DMSO : 33.33 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
NC1=CC(=C(C=C1)C)NC2=NC=CC(=N2)C3=CC=CN=C3
Molecular Formula
C16H15N5
Molecular Weight
277.33
Precautions
H302, H315, H319, H335
References & Citations
[1]Zimmermann J, et al. Phenylamino-pyrimidine (PAP) derivatives: a new class of potent and selective inhibitors of protein kinase C (PKC) . Arch Pharm (Weinheim) . 1996 Jul;329 (7) :371-6.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
EGFR/ErbB1/HER1; PKA; PKCα; PKCδ

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