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PKC-IN-4

CAT: 0931-T61604-01Size: 25 mgDry Ice: NoHazardous: No
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CAT#:0931-T61604-01Size:25 mg
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2636771-29-2
Target
Others, PKC
Related Pathways
Cytoskeletal Signaling, Chromatin/Epigenetic, Others
Bioactivity
PKC-IN-4 (compound 7l) is a highly potent and orally active inhibitor of atypical protein kinase C (aPKC), with an IC 50 value of 0.52 μM. In vitro studies show that PKC-IN-4 effectively suppresses NF-κB activity induced by TNF-α and impedes retinal vasculature permeability induced by both VEGF and TNF-α. [1]
Smiles
C(N)C1CCN(C2=C3C(SC4=C3CCCC4)=NC(=N2)C=5C=CN=CC5)CC1
Molecular Formula
C21H25N5S
Molecular Weight
379.52
Shipping Conditions
Ice Packs
Storage Temperature
-20°C

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