RM-581

• Description:

  RM-581, an aminosteroid derivative, is an endoplasmic reticulum stress (ERS) inducer. RM-581 induces cancer cells apoptosis. RM-581 can be used for the study of pancreatic, prostate and breast cancers[1][2][3].

• UNSPSC:

  12352005

• Target:

  Apoptosis

• Type:

  Reference compound

• Related Pathways:

  Apoptosis

• Applications:

  Cancer-programmed cell death

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/rm-581.html

• Solubility:

  10 mM in DMSO

• Smiles:

  C[C@@]12[C@](CC[C@@]2(O)C#C)([H])[C@@]3([H])[C@@](CC1)([H])C4=CC(N5CCN(CC5)C([C@H]6N(CCC6)C(C7=NC8=C(C=CC=C8)C=C7)=O)=O)=C(OC)C=C4CC3

• Molecular Formula:

  C40H46N4O4

• Molecular Weight:

  646.82

• References & Citations:

  [1]René Maltais, et al. Minor chemical modifications of the aminosteroid derivative RM-581 lead to major impact on its anticancer activity, metabolic stability and aqueous solubility. Eur J Med Chem. 2020 Feb 15;188:111990.|[2]Donald Poirier, et al. Abstract 5639: A potent aminosteroid (RM-581) that inhibits orally in mice the tumor growth in an orthotopic xenograft pancreatic cancer model. Cancer Res (2025) 85 (8_Supplement_1) : 5639.|[3]Donald Poirier, et al. Abstract 5748: Metabolites of the orally potent anticancer agent and endoplasmic reticulum stress inducer RM-581. Cancer Res (2025) 85 (8_Supplement_1) : 5748.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2086809-59-6]