RM-018

• Description :

  RM-018 is a potent, functionally distinct tricomplex KRASG12C active-state inhibitor. RM-018 retains the ability to bind and inhibit KRASG12C/Y96D and could overcome resistance. RM-018 binds specifically to the GTP-bound, active [“RAS (ON) ”] state of KRASG12C[1].

• UNSPSC :

  12352005

• Target :

  Ras

• Type :

  Reference compound

• Related Pathways :

  GPCR/G Protein; MAPK/ERK Pathway

• Applications :

  Cancer-Kinase/protease

• Field of Research :

  Cancer

• Assay Protocol :

  https://www.medchemexpress.com/rm-018.html

• Purity :

  95.50

• Solubility :

  DMSO : 60 mg/mL (ultrasonic)

• Smiles :

  O=C(N1CCC[C@@H](C(OCC(C)(C)CC2=[C@@]([C@@]3=C([C@H](C)OC)N=CC=C3)N(CC)C4=C2C=C5C=C4)=O)N1)[C@@H](NC([C@H](C(C)C)N(C)C([C@H]6CCN(C(C#CCN7CCOCC7)=O)C6)=O)=O)CC8=CC=CC5=C8

• Molecular Formula :

  C56H72N8O8

• Molecular Weight :

  985.22

• References & Citations :

  G12C

• Shipping Conditions :

  Room Temperature

• Storage Conditions :

  -20°C, 3 years; 4°C, 2 years (Powder)

• Scientific Category :

  Reference compound1

• Clinical Information :

  No Development Reported

• Isoform :

  K-Ras

• CAS Number :

  [2641993-55-5]