RM-018

CAT: 0804-HY-141477-01Size: 5 mgDry Ice: NoHazardous: No
CAT#:0804-HY-141477-01Size:5 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
RM-018 is a potent, functionally distinct tricomplex KRASG12C active-state inhibitor. RM-018 retains the ability to bind and inhibit KRASG12C/Y96D and could overcome resistance. RM-018 binds specifically to the GTP-bound, active [“RAS (ON) ”] state of KRASG12C[1].
CAS Number
[2641993-55-5]
UNSPSC
12352005
Target
Ras
Type
Reference compound
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/rm-018.html
Purity
95.50
Solubility
DMSO : 60 mg/mL (ultrasonic)
Smiles
O=C(N1CCC[C@@H](C(OCC(C)(C)CC2=[C@@]([C@@]3=C([C@H](C)OC)N=CC=C3)N(CC)C4=C2C=C5C=C4)=O)N1)[C@@H](NC([C@H](C(C)C)N(C)C([C@H]6CCN(C(C#CCN7CCOCC7)=O)C6)=O)=O)CC8=CC=CC5=C8
Molecular Formula
C56H72N8O8
Molecular Weight
985.22
References & Citations
G12C
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
K-Ras

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