AM-1488

• Description:

  AM-1488 is a potent, orally active glycine receptor (GlyR) potentiator (hGlyRα3 EC50=0.45 μM) [1][2].

• UNSPSC:

  12352005

• Hazard Statement:

  H315-H319-H335

• Target:

  Others

• Type:

  Reference compound

• Related Pathways:

  Others

• Applications:

  Neuroscience-Neuromodulation

• Field of Research:

  Neurological Disease

• Assay Protocol:

  https://www.medchemexpress.com/am-1488.html

• Solubility:

  10 mM in DMSO

• Smiles:

  O=C1[C@@]2 ([H]) [C@@] (CN (C2) S (=O) (C3=CC=C (OC=C4) C4=C3) =O) ([H]) C5=CN=CC=C5N1C

• Molecular Formula:

  C19H17N3O4S

• Molecular Weight:

  383.42

• Precautions:

  P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P362-P403+P233-P405-P501

• References & Citations:

  [1]Xin Huang, et al. Crystal structures of human glycine receptor α3 bound to a novel class of analgesic potentiators. Nat Struct Mol Biol. 2017 Feb;24 (2) :108-113.|[2]Howard Bregman, et al. The Discovery and Hit-to-Lead Optimization of Tricyclic Sulfonamides as Potent and Efficacious Potentiators of Glycine Receptors. J Med Chem. 2017 Feb 9;60 (3) :1105-1125.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  2079895-60-4