RET-IN-16

• Description:

  RET-IN-16 is a potent and selective RET inhibitor with IC50s of 3.98 nM, 8.42 nM, 15.05 nM, 7.86 nM, 5.43 nM and 8.86 nM for RET (WT), RET (M918T), RET (V804L), RET (V804M), RET-CCDC6 and RET-KIF5B, respectively. RET-IN-16 has anticancer effects[1].

• UNSPSC:

  12352005

• Target:

  RET

• Type:

  Reference compound

• Related Pathways:

  Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ret-in-16.html

• Solubility:

  10 mM in DMSO

• Smiles:

  CC1=CC=C(C=C1OC2=C3C=NNC3=NC(C4=CN=CC=C4)=N2)C(NC5=CC(C(F)(F)F)=C(C=C5)CN6CCN(CC6)C)=O

• Molecular Formula:

  C31H29F3N8O2

• Molecular Weight:

  602.61

• References & Citations:

  [1]Li X, Su J, Yang Y, et al. Discovery of 4-methyl-N- (4- ((4-methylpiperazin- 1-yl) methyl) -3- (trifluoromethyl) phenyl) -3- ((6- (pyridin-3-yl) -1H-pyrazolo[3,4-d]pyrimidin-4-yl) -oxy) benzamide as a potent inhibitor of RET and its gatekeeper mutant. Eur J Med Chem. 2020;207:112755.

• Shipping Conditions:

  Room temperature

• Scientific Category:

  Reference compound1

• Clinical Information:

  No Development Reported

• CAS Number:

  [2259657-48-0]