RET-IN-5

• UNSPSC Description:

  RET-IN-5 is a potent RET (rearranged during transfection) inhibitor with an IC50s of 0.4 nM and 135.1 nM for RET and VEGFR2, respectively (WO2021213476A1, compound 18)[1].

• Target Antigen:

  RET

• Type:

  Reference compound

• Related Pathways:

  Protein Tyrosine Kinase/RTK

• Applications:

  Cancer-Kinase/protease

• Field of Research:

  Cancer

• Assay Protocol:

  https://www.medchemexpress.com/ret-in-5.html

• Solubility:

  10 mM in DMSO

• Smiles:

  N#CC1=C2C(C3=CN=C(N(C)[C@H](C4=CN=C(N5C=C(C=N5)F)C=C4)C)C=C3)=CC(OCC(C)(C)C#N)=CN2N=C1

• Molecular Weight:

  535.57

• References & Citations:

  [1]Pyrazolo[1,5-a]pyridine derivative, preparation method therefor, and composition and use thereof. WO2021213476A1.

• Shipping Conditions:

  Room temperature

• Clinical Information:

  No Development Reported

• CAS Number:

  2725770-20-5