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RET-IN-5

CAT: 0804-HY-145023Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-145023Size:1 Each
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Description
RET-IN-5 is a potent RET (rearranged during transfection) inhibitor with an IC50s of 0.4 nM and 135.1 nM for RET and VEGFR2, respectively (WO2021213476A1, compound 18) [1].
CAS Number
2725770-20-5
UNSPSC
12352005
Target
RET
Type
Reference compound
Related Pathways
Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/ret-in-5.html
Solubility
10 mM in DMSO
Smiles
N#CC1=C2C(C3=CN=C(N(C)[C@H](C4=CN=C(N5C=C(C=N5)F)C=C4)C)C=C3)=CC(OCC(C)(C)C#N)=CN2N=C1
Molecular Formula
C29H26FN9O
Molecular Weight
535.57
References & Citations
[1]Pyrazolo[1,5-a]pyridine derivative, preparation method therefor, and composition and use thereof. WO2021213476A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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