RET-IN-1

RET-IN-1

• CAS Number: 2222755-14-6
• UNSPSC Description: RET-IN-1 is a RET kinase inhibitor extracted from patent WO2018071447A1, Compound Example 552, has IC50s of 1 nM, 7 nM, and 101 nM for RET (WT), RET (V804M) , and RET (G810R), respectively [1].
• Target Antigen: RET
• Type: Reference compound
• Related Pathways: Protein Tyrosine Kinase/RTK
• Applications: Cancer-Kinase/protease
• Field of Research: Cancer
• Assay Protocol: https://www.medchemexpress.com/ret-in-1.html
• Solubility: 10 mM in DMSO
• Smiles: N#CC1=C2C(C3=NC=C(N4CC(C5)N(CC6=CC=C(OC)N=C6)C5C4)N=C3)=CC(OC[C@H]7CNCCO7)=CN2N=C1
• Molecular Weight: 553.61
• References & Citations: [1]Steven W A, et al. Substituted pyrazolo[1,5-a]pyridine compounds as ret kinase inhibitors. WO2018071447A1.
• Shipping Conditions: Room temperature
• Clinical Information: No Development Reported