RET-IN-16

• Target:

  Others|||c-RET

• Related Pathways:

  Apoptosis|||Others|||Tyrosine Kinase/Adaptors

• Bioactivity:

  RET-IN-16 is a potent, selective inhibitor of RET, exhibiting IC50 values of 3.98 nM for RET (WT), 8.42 nM for RET (M918T), 15.05 nM for RET (V804L), 7.86 nM for RET (V804M), 5.43 nM for RET-CCDC6, and 8.86 nM for RET-KIF5B, indicating its high efficacy across different RET mutations. It possesses anticancer properties.

• Smiles:

  O (C1=C2C (=NC (=N1) C=3C=CC=NC3) NN=C2) C4=CC (C (NC5=CC (C (F) (F) F) =C (CN6CCN (C) CC6) C=C5) =O) =CC=C4C

• Molecular Formula:

  C31H29F3N8O2

• Molecular Weight:

  602.61

• Shipping Conditions:

  Cool pack

• Storage Temperature:

  -20°C

• CAS Number:

  2259657-48-0