RET-IN-16

CAT: 0931-T73256-01Size: 25 mgDry Ice: NoHazardous: No

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CAT#:0931-T73256-01Size:25 mg

Selected

24/48H Stock Items & 2 to 6 Weeks non Stock Items.

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CAS Number

2259657-48-0

Target

Others, c-RET

Related Pathways

Apoptosis, Others, Tyrosine Kinase/Adaptors

Bioactivity

RET-IN-16 is a potent, selective inhibitor of RET, exhibiting IC50 values of 3.98 nM for RET (WT), 8.42 nM for RET (M918T), 15.05 nM for RET (V804L), 7.86 nM for RET (V804M), 5.43 nM for RET-CCDC6, and 8.86 nM for RET-KIF5B, indicating its high efficacy across different RET mutations. It possesses anticancer properties.

Smiles

O(C1=C2C(=NC(=N1)C=3C=CC=NC3)NN=C2)C4=CC(C(NC5=CC(C(F)(F)F)=C(CN6CCN(C)CC6)C=C5)=O)=CC=C4C

Molecular Formula

C31H29F3N8O2

Molecular Weight

602.61

Shipping Conditions

Ice Packs

Storage Temperature

-20°C

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GTR19212272-01	RET-IN-16
R1701-17	RET protein (RET)
V8277-100UG	RET Antibody / c-RET
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332425-01	Ret

RET-IN-16

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