RET-IN-16

CAT: 0931-MF-0146616-01Size: 25 mgDry Ice: NoHazardous: No
CAT#:0931-MF-0146616-01Size:25 mg
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AVAILABILITY: InStock
24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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CAS Number
2259657-48-0
Target
Others|||c-RET
Related Pathways
Apoptosis|||Others|||Tyrosine Kinase/Adaptors
Bioactivity
RET-IN-16 is a potent, selective inhibitor of RET, exhibiting IC50 values of 3.98 nM for RET (WT), 8.42 nM for RET (M918T), 15.05 nM for RET (V804L), 7.86 nM for RET (V804M), 5.43 nM for RET-CCDC6, and 8.86 nM for RET-KIF5B, indicating its high efficacy across different RET mutations. It possesses anticancer properties.
Smiles
O(C1=C2C(=NC(=N1)C=3C=CC=NC3)NN=C2)C4=CC(C(NC5=CC(C(F)(F)F)=C(CN6CCN(C)CC6)C=C5)=O)=CC=C4C
Molecular Formula
C31H29F3N8O2
Molecular Weight
602.61
Shipping Conditions
Cool pack
Storage Temperature
-20°C

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