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SEH inhibitor-2

CAT: 0804-HY-143294Size: 1 EachDry Ice: NoHazardous: No
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CAT#:0804-HY-143294Size:1 Each
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24/48H Stock Items & 2 to 6 Weeks non Stock Items.
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Description
SEH inhibitor-2 (compound 5l) is an orally active (predicted percentage absorption: 71.2-88.4%) soluble epoxide hydrolase (sEH) inhibitor, with an IC50 of 0.9 nM. sEH inhibitor-2 can maintain epoxyeicosatrienoic acids (EETs) serum level in high concentrations. sEH inhibitor-2 can be used in study of cardiovascular protection[1].
CAS Number
2816102-69-7
UNSPSC
12352005
Target
Epoxide Hydrolase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Assay Protocol
https://www.medchemexpress.com/seh-inhibitor-2.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=CC=C1C(NC2=CC=C(C=C2)CN3C=C(N=N3)C4=CC=CC=C4)=O)O
Molecular Formula
C23H18N4O3
Molecular Weight
398.41
References & Citations
[1]Rezaee, E, et al. Design, synthesis, and biological evaluation of some 1,2,3-triazole derivatives as novel amide-based inhibitors of soluble epoxide hydrolase. Med Chem Res 30, 1738–1746 (2021) .
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported

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